Sex steroids, through their receptors, have potent effects on the signal pathways involved in osteogenic or myogenic differentiation. However, a considerable segment of those signal pathways has a prominent role in epithelial neoplastic transformation. The capability to intervene locally has focused on specific ligands for the receptors. Nevertheless, many signals are mapped to interactions of steroid receptor motifs with heterologous regulatory proteins. Some of those proteins interact with the glucocorticoid receptor and other factors essential to cell fate. Interactions of steroid (...) receptor domain motifs with heterologous proteins affect specific target pathways; consequently, manipulation of specified protein modules complexed with steroid receptors may be a next major step for enhancing molecular targeted therapeutics. In the future, intervention at specific sections of receptor primary sequence may prove therapeutically more efficient in targeting pathways of choice than ligand selectivity can be. (shrink)

It is inevitable that some inmates in large state prison systems will suffer from terminal conditions and die while incarcerated. But how those inmates experience that event is primarily controlled by correctional policies and by the prison medical and correctional staff assigned to their care. Compassion for inmates who are dying cannot be legislated or mandated, but humane and compassionate care for the dying can be facilitated or thwarted by legislative and correctional policies, and by the manner in which correctional (...) personnel interpret those policies.Death in New York State prisons is a frequent event, occurring at a rate substantially higher than that in most other states. With a prison population that has risen to 70,000 inmates and with the nation’s highest rate of human immunodeficiency virus infection, more than 2,817 inmates died in New York prisons during the period 1990-1998. In April 1992, in the face of an ever-increasing death rate in its prisons, the New York State legislature passed the Medical Parole Law, a measure designed to permit dying inmates to be released on parole prior to their normal release eligibility date. (shrink)

Logical consistency demands that Mercier and Sperber's (M&S's) argumentative theory of reasoning apply to their own reasoning in the target article. Although they hint that their argument applies to professional reasoners such as scientists and philosophers, they do not develop this idea. In this commentary, I discuss the applicability of argumentative theory to science and philosophy, emphasizing the perils of moral reasoning.

In Marc. gr., classis XI,18 an anonymous florilegium consisting of selected paragraphs of the Second Part of the Fifth Division of the 3rd book of Thomas Aquinas’ Summa contra Gentiles is extant. These paragraphs were excerpted from the Greek translation of the Latin text by Demetrios Cydones and 106 ; ch. 101, § 2 partim; 103; ch. 94, § 3-5; 12-15). The main topic of this text is «fate». An edition of it is offered, and it is argued, on the (...) basis of its similarity with another florilegium Thomisticum of the professed Byzantine Thomist Georgios Scholarios - Gennadios II as well as with some of his writings, that it must be attributed to the same author. It should be probably placed in 1444/53 and regarded as part of Scholarios’ preparation for refuting Georgios Gemistos - Plethon’s Laws II,6, which from 1439 onwards was circulated independently as De fato. (shrink)

This dissertation focuses on the contemporary debate over moving from an individualist form of liberalism to one that seeks to accommodate the special claims of various groups in modern society. I deal with authors who examine ways that group dynamics affect the individual. They are worried about whether it is possible or wise to extend individualist liberalism into a group-accommodating liberalism. Presently, it is a matter of deep controversy how liberal democracies ought to interpret and accommodate the social reality and (...) normative claims of racial minorities. ;Race denotes privilege, it precipitates class antagonisms, hostility, and anger between various groups, it motivates misconceptions and misunderstandings. Racism is responsible for both immediate and intergenerational harm. And yet, the members of disadvantaged racial groups see their racial identity as something precious that should be preserved. For many the opportunity to identify with others in terms of a common racial heritage is an important source of pride. This disparity poses special problems for philosophical liberalism. What is the philosophical import of race and racism for various political theories within the contemporary Anglo American tradition of individualist liberalism? How ought the liberal tradition, an individualist thesis, to interpret and accommodate racial identity? ;This dissertation casts the philosophical debate concerning race in a new light. I argue that whether racial identities are compatible with liberal democratic ideals depends on how one defines race and the liberal ideals involved. Hence, I urge a critical stance on the issue of race. I am critical of both classical individualist liberalism, and the stand that groups do not pose any problems in a modern liberal democracy. (shrink)

I argue that we do not get an adequate picture of society from liberal conceptions of race and racism. What this analysis does, then, is call for a synthesis of historical, social, and cultural insights to inform and enrich the philosophical conception of race and racism.

Müller argues that double dissociations do not imply underlying modularity of the cognitive system, citing neural networks as examples of fully distributed systems that can give rise to double dissociations. We challenge this claim, noting that suchdouble dissociations typically do not “scale-up,” and that even some singledissociations can be difficult to account for in a distributed system.

The white‐rot fungus Phanrochaete chrysosporium has the ability to degrade a wide variety of structurally diverse organic compounds, including a number of environmentally persistent organopollutants. The unique biodegradative abilities of this fungus appears to be dependent upon its lignin‐degrading system. The non‐specific and partially extracellular nature of this system suggests that it may be useful as a supplementary means to treat organochemical wastes.

Commentators on empirical research in business ethics have recommended that use should be made of meta-analysis – the quantitative analysis of a group of research studies. This paper elaborates upon those recommendations by conducting, as a "case study" for further reflection, a meta-analysis of studies of accountants' organizational-professional conflict (OPC) previously published in accounting and psychology journals. Of five variables capable of analysis, only the population correlation coefficient between OPC and organizational tenure is identified. It was not possible to find (...) the population correlation coefficient of the other four variables, for which several possible reasons are suggested. The paper then shows how meta-analysis can make a valuable contribution, even when the substantive findings are limited, by providing guidance for future research and a safeguard against the drawing of unjustified conclusions, to which the more usual narrative reviews of literature are prone. (shrink)

This paper reexamines the thesis of a split between politics and morality in the political theory of the eighteenth century. At its center is the notion of a “civil society” and the safeguards necessary for its proper functioning. While arguments are drawn from several discourses (economic, juridical, political, ethical), the focus is on the political and ethical reasoning of the age derivative of natural law and dependent upon the free and open exchange of ideas.

Science (episteme) -- Division of the sciences according to aims and objects -- Demonstration (apodeixis) -- The axioms of the sciences -- Being or substance (ousia) -- Being before aristotle -- Being in the categories -- The science of being: first philosophy -- Being in metaphysics zeta -- Nature (physis) -- Principles of change -- The four causes or explanations (aitiai) -- Defense of teleology -- Soul (psyche) -- Soul as substance, form and actuality -- What the student of soul (...) investigates -- Perception -- Thought -- Success (eudaimonia) -- The practical science of ethics -- The chief and final good for human beings -- Virtues of character -- Virtues of intellect. (shrink)

The cognitive sciences may be understood to contribute to religion-and-science as a metadisciplinary discussion in ways that can be organized according to the three persons of narrative, encoding the themes of consciousness, relationality, and healing. First-person accounts are likely to be important to the understanding of consciousness, the "hard problem" of subjective experience, and contribute to a neurophenomenology of mind, even though we must be aware of their role in human suffering, their epistemic limits, and their indirect causal role in (...) human behavior and subsequent experience. Second-person discussions are important for understanding the empathic and embodied relationality upon which an externalist account of mind is likely to depend, increasingly uncovered and supported by social neuroscience. Third-person accounts can be better understood in uncovering the us/them distinctions that they encode and healing the dangerous tribalisms that put an interdependent and communal world increasingly at risk. (shrink)

Arrow's Theorem, in its social choice function formulation, assumes that all nonempty finite subsets of the universal set of alternatives is potentially a feasible set. We demonstrate that the axioms in Arrow's Theorem, with weak Pareto strengthened to strong Pareto, are consistent if it is assumed that there is a prespecified alternative which is in every feasible set. We further show that if the collection of feasible sets consists of all subsets of alternatives containing a prespecified list of alternatives and (...) if there are at least three additional alternatives not on this list, replacing nondictatorship by anonymity results in an impossibility theorem. (shrink)

Recent research suggests an “Internet paradox”—that a communications technology might reduce social involvement and psychological well–being. In this article I examine some of the limitations of current Internet communication, including those of access, medium, presentation, and choice, that bear on the formation and maintenance of social relationships. I also explore issues central to human meaning in a technological culture—those of the history of the self, of individuality, and of human relationships—and suggest that social forces, technological and otherwise, have increasingly eroded (...) our social interconnectedness and even produced psychological fragmentation. Finally, by considering the psychology of privacy, subjectivity, and intimacy, I look at the historical and developmental processes of internalization by which we construct the “virtual interior” of mind. Understanding this link between human meaning and technological culture, in the form and pattern of our virtual interiors, may help us to see opportunities as well as dangers for the growth of our humanity, our ethics, and our spirituality. (shrink)

Spiritual life is made possible by the evolution of a human neuropsychology that requires social interdependence for its development. Extensive neuroplasticity requires experiential shaping throughout life. The evolution of frontal cortex hypertrophy suggests that much of this shaping is produced by a socially constructed virtual reality, extending beyond immediate experience. Prefrontal colonization makes possible the social scaffolding of neuroregulation, including the emotional attachments necessary for moral life. Cognitive independence from immediate environments enables symbioses with external memory systems, producing novel forms (...) of socially constituted experience and making possible the transformative effect of religious systems upon individual biologies and psychologies. (shrink)

This book constructs a new scientific explanation of the causes of war. The author describes systematically those factors common to wars between equal states to see if there is a pattern that suggests why war occurs and delineates the typical path by which relatively equal states have become embroiled in wars with one another in the modern global system. The book differs from others in that it employs the large number of empirical findings generated in the past twenty-five years to (...) solve the puzzle of war and peace. (shrink)

This study examines Itō Jinsai’s 伊藤仁斎 (1627–1705) criticisms of the Great Learning (C: Daxue 大學 J: Daigaku). Three primary sources are considered: Jinsai’s Shigi sakumon 私擬策問 (Personal Essays, 1668); the Daigaku teihon 大學定本 (The Definitive Text of the Great Learning, manuscript 1685); and his essay, “Daigaku wa Kōshi no isho ni arazaru no ben” 大學非孔氏之遺書辨 (The Great Learning is not a Writing Confucius Transmitted, 1705), appended to his Gomō jigi 語孟字義. The study suggests that Jinsai’s critical inclinations grew from his (...) acceptance of Zhu Xi’s views about the value of doubt for progress in learning. The study also suggests that Jinsai’s thinking on the Great Learning had political implications derived in many respects from Jinsai’s overall approach to philosophizing via analysis of words and their meanings. (shrink)

Abstract. Concepts of individual autonomy underlie much of contemporary self-understanding, including the institutions and ways of living in modern societies. These concepts of autonomy are complex, even contradictory, and may present problems for our future. This overview sketches the narrative arc of a collection of papers addressing these topics. While autonomy and individuality are not fictions, neither do what we take to be individuality or autonomy have an unchanging reality. We are both influenced by and have an influence upon how (...) these concepts are understood and used, and their implications for our history, our morality, our religious life, and the future of our relationships and our communities. (shrink)

This paper explores research in educational psychology and learning theory in a search for insights to enhance business ethics training Useful educational principles uncovered are then applied to the development of an ethics training initiative for sales professionals. The paper concludes with suggestions for future research to help enrich business ethics training.

Understanding purpose and intent requires attention to our experience of time. Cognitive neuroscientific research into the functional and neural substrates of higher cognitive functions have direct bearing on the experience of temporal ordering. Consciousness, located within the short span of working memory, is made cognitively possible and evolutionarily valuable by biological constraints in time. These constraints, including our longevity, make thought about more extended events both possible and useful. Such cognitive processes, rooted in the neurophysiology of cortical function, are a (...) sine qua non for the construction of meaning, relationship, morality, and purposes that may extend beyond our mortality. Research in the cognitive neurosciences is overviewed, and implications are discussed for questions of mortality, design and intention, the reconstruction of meaning, and the experience of eternity. (shrink)

Differences of understanding in science and in religion can be explored via the distinction between paradigmatic and narrative modes of explanation. Although science is inclusive of the paradigmatic, I propose that in explaining the behavior of complex adaptive systems, and in the human sciences in particular, narratives may well constitute the best scientific explanations. Causal relationships may be embedded within, and expressions of higher-order constraints provided by, complex system dynamics, best understood via the temporal organization of intentionalities that constitute narrative. (...) Complex adaptive systems, out of which intentions emerge, have behavioral trajectories that are in principle unique, contingent, and nondeterministic even in stable states and unpredictable across phase transitions. Given such unpredictability, the only explanation can be an interpretive story that retrospectively retraces the actual changes in dynamics. Without narrative, personality traits and human actions are incomprehensible. Such phenomena do not permit a reduction of purposive acts to nonpurposive elements or of reasons to the causes they constrain. Causality does not exhaust meaning. Given the role of narratives in human lives, religion and mythology provide larger stories within which individual stories make sense. Differences between narrative and historical truth suggest how we can be constituted by what we imagine ourselves to be. (shrink)

Understanding the human spirit, the thinking, motivating, feeling aspect of a person, need not entail supernatural reference in any more than a boundary sense. Methodological naturalism accounts for many putatively supernatural experiences in terms of naturalistic and scientific research. Fairy tales have natural functions, naturalistic accounts of miracles can have moral and spiritual power, and neuropsychological research can have value in understanding experiences of ghosts, apparitions, and presences. Even beliefs in personal immortality, at odds with current neurobiology, may serve a (...) range of psychological functions and may raise more moral questions than they answer. Naturalistic accounts can make spiritual explorations possible where supernatural answers provide epistemic barriers. (shrink)

This is a translation of the chapter on perception by Kumarilabhatta's magnum opus, the Slokavarttika , which is one of the central texts of the Hindu response to the criticism of the logical-epistemological school of Buddhist thought. It is crucial for understanding the debates between Hindus and Buddhists about metaphysical, epistemological and linguistic questions during the classical period. In an extensive commentary, the author explains the course of the argument from verse to verse and alludes to other theories of classical (...) Indian philosophy and numerous other technical matters. Notes to the translation and commentary go further into the historical and philosophical background of Kumarila's ideas. The book provides an introduction to the history and the development of Indian epistemology, a synopsis of Kumarila's work and an analysis of its argument. It is a valuable contribution to the field of Indian philosophical studies. (shrink)

These original essays offer new perspectives for science educators, curriculum theorists, and cultural critics on science education, French post-structural thought, and the science debates. Included in this book are chapters on the work of Bruno Latour, Michel Serres, and Jean Baudrillard, plus chapters on postmodern approaches to science education and critiques of modern scientific assumptions in curriculum development.